Mitochondrial Intermembrane Space

E embedded in the inner mitochondrial membrane.

Mitochondrial intermembrane space. Green in methods in enzymology 2000. Simplified structure of a mitochondrion the intermembrane space ims is the space occurring between or involving two or more membranes. The mitochondrial intermembrane space ims harbors a diverse set of proteins that fulfill important tasks e g in mitochondrial protein import detoxification of reactive oxygen species and.

The matrix and the intermembrane space. It is also known as perimitochondrial space. The mitochondrial intermembrane space ims houses a large spectrum of proteins with distinct and critical functions.

In living cells cytochrome c is confined to the mitochondrial intermembrane space where it participates as an electron carrier in the respiratory chain in apoptotic cells cytochrome c leaves its normal mitochondrial localization and accumulates in the cytoplasm where it binds to the adaptor molecule apaf 1. Channel protein s called porins in the outer membrane allow free movement of ions and small molecule s into the intermembrane space. Mitochondria contain two aqueous compartments.

Protein import into this mitochondrial sub compartment is underpinned by an intriguing variety of pathways many of which are still poorly understood. Since both mitochondrial membranes are only a few nanometers apart the ims is a rather tiny compartment of the cell. Mitochondria contain two aqueous compartments.

D located in the mitochondrial matrix. The constricted volume of the ims and the. B located in the intermembrane space of mitochondria.

A embedded in both mitochondrial membranes. Whereas many of the biologic functions of the matrix were well characterized in the past it became clear very recently that the intermembrane space plays a pivotal role in the coordination of mitochondrial activities with other cellular processes. The intermembrane space is the region between the inner membrane and the outer membrane of a mitochondrion or a chloroplast.