Space Of Disse

Blood cells and platelets are excluded.

Space of disse. The space of disse is localized among the lsecs and neighboring hepatocytes due to the loss of the basement membrane between the two 6. In the perisusoidal space the hepatic stellate cells are located. It is filled with the blood plasma.

Apoe is secreted into the space of disse by the hepatocyte. The disse space lies between hepatocytes and the sinusoids and is also referred to as the perisinusoidal space. The disse space cannot be visualized on an h e slide from a normal liver but is visible as a narrow tissue space in electron micrographs see fig.

The space of disse is also called the perisinosoidal space. The hepatocytes have many microvilli which project into this space to increase absorption from the plasma. The disse space contains stellate cells also called ito cells or lipocytes.

It was named after the german anatomist and histologist joseph hugo vincenz disse. The space of mall is located at the portal canal and is the region between the connective tissue and the liver parenchymal cells. It is also called the space of disse.

The perisinusoidal space or space of disse is a location in the liver between a hepatocyte and a sinusoid. It is the space between the liver sinusoids and the hepatocytes. This space separates hepatocytes which are lined with a low density basal membrane from endothelial cells which form the walls of the hepatic sinusoids.

Loss of the characteristic pores of endothelial cells or fenestrations is an early event in hepatic injury and is accompanied by secretion of ecm into the space of disse by hscs 11 12. Also apoe might stillbe on the remnants if not lost when shedding excess coat material. The space as a fine slit between the sinusoid lining cells the hepatocytes the space of disse is at the limit of the resulution of the lm.